Protein Details: Glutamate [NMDA] receptor subunit 1

Protein ID

ICDB_Pro_0093

Protein Name

Glutamate [NMDA] receptor subunit 1

Gene Name

Nmdar1; GJ24560

Organism

Drosophila virilis (Fruit fly)

Length

984 amino acids

AlphaFoldDB

AF-B4LZB5-F1-model_v4.pdb

Function

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity

Sequence

MAAAFAYRWLLCAAGIVNVLPIGAQRHTASDNPSTYNIGGVLSNSESELHFHTTIAHLNFDQQYVPRKVTYYDKTIRMDKNPIKTVFNVCDKLIEKRVYAVVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLRTVPPYYHQADVWLELLSHFLYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVRATVELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQALHANNTPDGVLGLQLEHAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREHQKQHLVGKFSYDSLRAKMRMRINDSEIIWGGKQKRKPEGIMIPTHLKVLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNASDATTNEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATVKGSSVDMYFRRQVELSNMYRTMESNNYVTAEQAIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGVGLQKGSPWTDAVTLTILEFHESGFMEKLDKQWIFHGHVQQNCELFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAADKWRGTIEKRKTIRASLAMQRQYNVGLMARQPPGTISLAVDKRRYPRLGQRLGPERAWPGDAADVLRTRRPYDLTKSGLVPPALGLGKTRPQQNPLPPRYSPGYTSDVSHLVV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

527..529;534;700;744

Disease

Location

DOI ID

10.1038/nature06341

RefSeq

XP_002054630.1; XP_015027744.1